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Example Input Mode:
Partner Data
CBIS
Matrix
Example Data Type:
Secondary Screen (Kd)
Primary Screen(% control or competition)
If the input file contains Primary and Secondary Data, use:
Primary
Secondary
Assay Data File:
.txt or .csv format - download examples:
Bromodomain
Kd
Primary
To highlight spots, select a compound(s), click 'fill' and select entries.
Create Images for:
CP-690550
Highlight These Spots (
fill
):
CP-690550|BIKE|7100
CP-690550|CAMK1|1200
CP-690550|CAMK1D|1600
CP-690550|CAMK2A|3500
CP-690550|CAMK2D|2700
CP-690550|DCAMKL1|6700
CP-690550|DCAMKL3|12
CP-690550|DMPK|1200
CP-690550|FYN|1100
CP-690550|GRK7|4300
CP-690550|JAK1(JH1domain-catalytic)|1.6
CP-690550|JAK2(JH1domain-catalytic)|0.58
CP-690550|JAK3(JH1domain-catalytic)|0.16
CP-690550|LCK|460
CP-690550|LRRK2|1300
CP-690550|MAP4K2|4800
CP-690550|MKNK2|1600
CP-690550|PKN1|170
CP-690550|PKN2|1200
CP-690550|PRKCD|2000
CP-690550|ROCK1|470
CP-690550|ROCK2|420
CP-690550|RSK1(Kin.Dom.2-C-terminal)|1400
CP-690550|RSK3(Kin.Dom.2-C-terminal)|600
CP-690550|RSK4(Kin.Dom.2-C-terminal)|540
CP-690550|SNARK|240
CP-690550|TNK1|120
CP-690550|TYK2(JH1domain-catalytic)|4.8
CP-690550|ULK3|6400
CP-690550|BIKE
CP-690550|CAMK1
CP-690550|CAMK1D
CP-690550|CAMK2A
CP-690550|CAMK2D
CP-690550|DCAMKL1
CP-690550|DCAMKL3
CP-690550|DMPK
CP-690550|FYN
CP-690550|GRK7
CP-690550|JAK1(JH1domain-catalytic)
CP-690550|JAK2(JH1domain-catalytic)
CP-690550|JAK3(JH1domain-catalytic)
CP-690550|LCK
CP-690550|LRRK2
CP-690550|MAP4K2
CP-690550|MKNK2
CP-690550|PKN1
CP-690550|PKN2
CP-690550|PRKCD
CP-690550|ROCK1
CP-690550|ROCK2
CP-690550|RSK1(Kin.Dom.2-C-terminal)
CP-690550|RSK3(Kin.Dom.2-C-terminal)
CP-690550|RSK4(Kin.Dom.2-C-terminal)
CP-690550|SNARK
CP-690550|TNK1
CP-690550|TYK2(JH1domain-catalytic)
CP-690550|ULK3
CP-690550|BIKE|7100
CP-690550|CAMK1|1200
CP-690550|CAMK1D|1600
CP-690550|CAMK2A|3500
CP-690550|CAMK2D|2700
CP-690550|DCAMKL1|6700
CP-690550|DCAMKL3|12
CP-690550|DMPK|1200
CP-690550|FYN|1100
CP-690550|GRK7|4300
CP-690550|JAK1(JH1domain-catalytic)|1.6
CP-690550|JAK2(JH1domain-catalytic)|0.58
CP-690550|JAK3(JH1domain-catalytic)|0.16
CP-690550|LCK|460
CP-690550|LRRK2|1300
CP-690550|MAP4K2|4800
CP-690550|MKNK2|1600
CP-690550|PKN1|170
CP-690550|PKN2|1200
CP-690550|PRKCD|2000
CP-690550|ROCK1|470
CP-690550|ROCK2|420
CP-690550|RSK1(Kin.Dom.2-C-terminal)|1400
CP-690550|RSK3(Kin.Dom.2-C-terminal)|600
CP-690550|RSK4(Kin.Dom.2-C-terminal)|540
CP-690550|SNARK|240
CP-690550|TNK1|120
CP-690550|TYK2(JH1domain-catalytic)|4.8
CP-690550|ULK3|6400
clear
Select Highlight spots color from Pallette:
(also used in table view)
Tree Image Options
Restore default options
Spot options:
IndianRed
PaleGreen
Gold
PowderBlue
Fill?
Outline?
Outline thickness:
1
2
3
4
5
Select Spots Color from Pallette:
(spot highlight color below)
micro
nano
Spot Size:
Scaling Factor:
.1
.2
.3
.4
.5
.6
.7
.8
.9
1
1.1
1.2
1.3
Area increase factor:
100%
90%
80%
70%
60%
50%
(per change of 10x Kd or 10% Competition)
Legend options:
Left align Text
Right align Text
Label options:
Compound Name?
Compound Name Font:
.5
1
1.5
2
Show Assay Panel information?
Show Panel Spots?
Append Concentration? (i.e., 'AB500@1000nm'; check before loading.)
Background Image:
Target labels?
Dark Tree Branch image?
Hide Lipid, Mutant, ATypical and Pathogen?
Spot options:
Spot Color transparency level:
none
low
medium-low
medium
high
no color
Spot Cutoff Value:
Kd (nM) (Blank for no cutoff)
Spot outline only?
Format:
JPEG(200KB per image)
Publication Quality(5MB image)
Create Publication Quality (5MB bitmap) Image for:
Select Compound
CP-690550
size/quality
100
90
80
70
60
50
40
30
% of original
White Space Border:
Yes
No
Preview and Highlighting
Highlight an assay by clicking on the spot or checking the box next to the Gene Symbol Name.
Click 'Update' to create the new images.
Compound To Highlight:
None
CP-690550
Highlight Panel?
* WildType kinase assays appear in both the main TREEspot and Mutant kinase dendrogams.
Human Kinome image created by KINOMEscan.
2 images created. To download (copy and paste) all images to your local machine click Open/Browse Image Folder.
Images Saved To:
D:\Eurofins\PROD\Applications\FrontOffice_Discovery\StudyManagement\TreeSpot\HTSTools\TreeImages\283_1sfz2jzr331ep0eenbhamzwc\
Open/Browse Image Folder
View Options:
(These options do not modify the images that have been created, only the view on this page)
CP-690550
Legend
Show Selected
Size:
Select Size
small
medium
full size
Images per Row:
1
Legend Resize?
Hover the cursor to identify spots and click to highlighted it. To save an image click the Zoom/Download link.
Zoom/Download
Highlight
Locate an Assay
CAMK1
CAMK1D
CAMK2D
DCAMKL3
DMPK
FYN
JAK1(JH1domain-catalytic)
JAK2(JH1domain-catalytic)
JAK3(JH1domain-catalytic)
LCK
LRRK2
LRRK2
MKNK2
PKN1
PKN2
PRKCD
ROCK1
ROCK2
RSK1(Kin.Dom.2-C-terminal)
RSK3(Kin.Dom.2-C-terminal)
RSK4(Kin.Dom.2-C-terminal)
SNARK
TNK1
TYK2(JH1domain-catalytic)
Legend
Data Table View:
Show All Data
Only Selected Compounds/Trees
TREE
spot
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